New publications of BETPSY

 

September 2021 - Immunopathogenesis and proposed clinical...

September 2021 - Immunopathogenesis and proposed clinical...

Vogrig and al. describe the mechanisms of spontaneous cancer regression and concomitant development of encephalitis regarding KLHL11-Ab syndromes and proose a new score for diagnosis (MATCH).

Agust 2021 - Article: Argonaute Autoantibodies as Biomarkers

Agust 2021 - Article: Argonaute Autoantibodies as Biomarkers

Do and al identified and characterized Argonote antibodies as novel biomarkers for patients with central and peripheral neurologic diseases.

June 2021 - Review: Fundamental mechanistic....

June 2021 - Review: Fundamental mechanistic....

This review summarizes key mechanistic insights into three such rare but paradigmatic neuroimmunological diseases.

May 2021- Article: Updated Diagnostic Criteria for Paraneoplastic...

May 2021- Article: Updated Diagnostic Criteria for Paraneoplastic...

This article presents the updated diagnostic criteria for paraneoplastic neurologic syndromes. A collaborative effort from 19 experts from 8 coutries to enhance the clinical care of patients and to encourage standardization of PNS research initiatives.

April 2021 - Article: Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis...

April 2021 - Article: Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis...

This paper proposes a description of (still rare) anti-AK5 encephalitis: predominantly older men with episodic amnesia and depression, prominent weight loss/anorexia, progressive atrophy, poor response to immunotherapy, strong HLA association and likely T cell-mediated pathogenesis.

March 2021 - Article: Clinical and Prognostic Value of Immunogenetic...

March 2021 - Article: Clinical and Prognostic Value of Immunogenetic...

Muñiz-Castrillo and al. aimed to investigate whether clinical or immunologic differences exist among patients with anti-LGI1 LE according to CSF positivity for LGI1-Abs and HLA-DRB1*07:01 carrier status. 

March 2021 - Review: Neurologic Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review...

March 2021 - Review: Neurologic Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review...

This article propose a defination of the clinical characteristics, management, and outcome of neurological immune-related adverse events (n-irAEs) of immune checkpoint inhibitors (ICIs). 

Februrary 2021 - Article: Familial autoimmunity in neurological patients with GAD65...

Februrary 2021 - Article: Familial autoimmunity in neurological patients with GAD65...

New article from Dr Muñiz-Castrillo and al. These results suggest a heterogeneous genetic predisposition to GAD65 neurological disorders, possibly involving multiple loci and modes of inheritance with different contribution in each family.

January 2021 - Article: CIDP antibodies target junction proteins...

January 2021 - Article: CIDP antibodies target junction proteins...

Moritz and al. proposes systemic characteristics in the repertoires of targeted autoantigens in chronic inflammatory demyelinating polyneuropathy (CIDP).

December 2020 - Article: Cranial nerve disorders associated...

December 2020 - Article: Cranial nerve disorders associated...

This paper from Vogrig and al. describes the spectrum, treatment, and outcome of cranial nerve disorders associated with immune checkpoint inhibitors.

October 2020 - Article: Proper definition of the set of autoantibody...

October 2020 - Article: Proper definition of the set of autoantibody...

For autoimmune-related diseases, a novel approach systemically analyzes entire antibody sets in an omics-like manner. How to properly define these sets has been shown by Moritz and al.

August 2020 - Article: Diagnostic des encéphalites auto-immunes

August 2020 - Article: Diagnostic des encéphalites auto-immunes

This article from Muñiz-Castrillo and al. briefly review the clinical presentation and the ancillary tests leading to a probable or definite diagnosis, which is the first step towards adequate management of these patients.

August 2020 - Article: Epidemiology of paraneoplastic neurologic syndromes...

August 2020 - Article: Epidemiology of paraneoplastic neurologic syndromes...

Hébert and al report the observed and expected incidence rates of paraneoplastic neurologic syndromes (PNSs) and autoimmune encephalitides (AEs) diagnosed in France between 2016 and 2018 using a population-based epidemiologic study.

July 2020 - Article: Anti-CASPR2 clinical phenotypes correlate...

July 2020 - Article: Anti-CASPR2 clinical phenotypes correlate...

In this paper, Dr Muñiz-Castrillo and al. present some physiopathological clues by studying whether the immunological and genetic (HLA) characteristics differed according to the clinical phenotypes.

July 2020 - Review: Fundamental mechanisms of autoantibody-induced...

July 2020 - Review: Fundamental mechanisms of autoantibody-induced...

This review's aim is to evaluate what kind of cerebellar ion channels, their related proteins, and the synaptic machinery proteins that are preferably impaired by autoantibodies so as to develop cerebellar ataxias (CAs).

June 2020 - Article: Transient neurological symptoms preceding...

June 2020 - Article: Transient neurological symptoms preceding...

Pr Honnorat team describes a transient clinical features preceding immune-mediated CA with GAD-Abs, in order to provide clues for an early diagnosis.

June 2020 - Article: Central nervous system complications associates...

June 2020 - Article: Central nervous system complications associates...

This article describes the spectrum and outcome of central nervous system complications associated with immune checkpoint inhibitors (CNS-ICI).

June 2020 - Review: Pathophysiology of paraneoplastic autoimmune...

June 2020 - Review: Pathophysiology of paraneoplastic autoimmune...

Pr Honnorat team provides a comprehensive review of the most recent findings in the field of PNSs and AEs, with particular focus on their triggering factors and immunopathogenesis.

June 2020 - Review: Immunological bases of paraneoplastic cerebellar...

June 2020 - Review: Immunological bases of paraneoplastic cerebellar...

Pr Liblau's team review recent literature pertaining to the pathophysiology of PCD and propose an immune scheme underlying this disabling disease.

May 2020 - Article: Clinical spectrum and diagnostic pitfalls of neurologic...

May 2020 - Article: Clinical spectrum and diagnostic pitfalls of neurologic...

In this article are presented the descritption of the main syndrome and clinical course in a large cohort of patients with anti–Ri-associated paraneoplastic neurologic syndrome (Ri-PNS).

May 2020 - Letter: Anti-Hu associated paraneoplastic syndromes triggered...

May 2020 - Letter: Anti-Hu associated paraneoplastic syndromes triggered...

This article provides the description of two patients with SCLC treated with ICIs who developed sensory neuronopathy (Case 1) and cerebellar degeneration (Case 2) in association with Hu-Abs.

May 2020 - Letter: Value of onconeuronal antibodies in checkpoint...

May 2020 - Letter: Value of onconeuronal antibodies in checkpoint...

Vogrig and al. expose their disagreement about statements made by Dubey and al concerning patients with n‐irAEs.

March 2020 - Article: Long-term outcomes in temporal lobe epilepsy..

March 2020 - Article: Long-term outcomes in temporal lobe epilepsy..

This article proposes to assess the long-term outcomes of patients with temporal lobe epilepsy and CSF anti-glutamate decarboxylase antibodies (GAD65-Abs).

March 2020 - Article: Primary DQ effect in the association between...

March 2020 - Article: Primary DQ effect in the association between...

Muñiz-Castrillo and al. present a study which fully describe the HLA haplotypes present in patients with neurological syndromes with GAD65-Ab and establish whether differences in HLA profiles exist according to the neurological clinical presentation or the co-occurrence of other organ-specific autoimmune diseases.

March 2020 - Article: Diagnostic yield of commercial immunodots to....

March 2020 - Article: Diagnostic yield of commercial immunodots to....

This paper proposes to investigate the diagnostic yield of commercial immunodots to detect onconeural antibodies associated with paraneoplastic neurologic syndromes (PNSs), we analyzed the proportion of confirmed positive results using alternative techniques.

January 2020 - Article: Epidemiology of paraneoplastic neurological...

January 2020 - Article: Epidemiology of paraneoplastic neurological...

This paper presents the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy.

January 2020 - Review: Association between HLA and autoimmune...

January 2020 - Review: Association between HLA and autoimmune...

Muñiz-Castrillo and al. report the main alleles and haplotypes, and discuss the clinical and pathogenic implications of these findings.