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 BETPSY Project

 

Biomarkers in autoimmune EncephaliTis and

Paraneoplastic neurological SYndromes

 

 

 

 

Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis.

The BETPSY project will benefit to patients with rare neuroimmune syndroms such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.

This project is coordinated by Professor Jérôme Honnorat, PU-PH, head of the neuro-oncology department at the Neurological hospital of Lyon and also director of the French rare disease reference center “paraneoplastic neurological syndrome and autoimmune encephalitis” since 2007.

BETPSY project has been awarded 7.3 million euros by the "Programme d'Investissement d'avenir (PIA)", and is based on a collaboration between 5 academic research teams (UCBL, HCL, ICM, CLB and INSERM), and 1 private company Euroimmun, which is specialized in the development of diagnostic kits to identify autoantibodies. The team of J. Honnorat in the MeLiS (Inserm U1314-CNRS/UCBL UMR5284) called “SynatAc” is totally dedicated to the study of the pathophysiological role of autoantibodies associated to AE and PNS. This team works for many years with Partners from CLB and ICM, to understand the role of tumor antigens in the immune reactions of PNS. The team from INSERM published a first animal model of PNS that will be very useful to decipher the role of T and B cells in PNS. 

Encephalitis International

Encephalitis International

A global resource for people affected directly or indirectly by encephalitis, an inflammation of the brain. Our vision is a world aware of encephalitis, its consequences and the support available. Our mission is to increase global awareness of encephalitis, saving lives and building better futures
Conference Pr Dalmau

Conference Pr Dalmau

Dr. Josep Dalmau speaker at "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"
The Anti-NMDA receptor Encephalitis Foundation

The Anti-NMDA receptor Encephalitis Foundation

The Anti-NMDA Receptor Encephalitis Foundation, Inc. was established in Canada as a not-for profit-foundation on 26 October 2012 and obtained charitable status from the Canada Revenue Agency on 25 March 2013
What is AE Alliance?

What is AE Alliance?

The Autoimmune Encephalitis Alliance was started by families and patients affected by autoimmune encephalitis. Founded in 2012 the AE Alliance is a non-profit organization based in Durham North Carolina