Workpackages
WP1
Prospective collection of patient cohorts with PNS and AE
Improve cohorts of patient biological samples and controls for the translational research programs. Collect and prepare biological samples that will be used in other WPs by industrial and academic partners.
WP2
Identification and validation of new autoantibodies as biomarkers
Identify new diagnostic, prognostic or treatment efficiency biomarkers, to validate their clinical values using human biological samples collected in WP1, and test some specific promising targets characterized in WP 3, 4 and 5
WP3
Genetic biomarkers and HLA haplotyping
Identify genetic factors according to the clinical and immune diversity of the autoimmune encephalitis and paraneoplastic neurological syndromes.
WP4
Use the exceptional collection of PNS-associated tumors of the French reference center to better characterize the tumor abnormalities leading to the immune disease and to characterize PNS specific B and T cell responses amenable to new biomarkers development.
WP5
Identification of immune cell biomarkers using models of PNS
Develop two specific animal models to study the pathophysiology of PNS. These models offer the opportunity to decipher the specific role of B and T cells, to identify clearly the antigens able to breakdown the immune system, to identify new potential prognostic biomarkers and to propose new treatment strategies.
WP6
Management, valorisation and dissemination
Maximize the expected impact of the BETPSY project, develop an integrative approach of the PNS and AE biomarkers and measure the impact of BETPSY on the diagnosis and patient care of AE and PNS in France.
