Pathophysiology of paraneoplastic autoimmune...

Very recently, it was shown that both PNSs and AEs can be triggered by cancer immunotherapy, in particular immune checkpoint inhibitor (ICI) treatment. Despite many advances in clinical characterization and Ab detection, the pathogenesis of immune tolerance breakdown in the setting of PNSs and AEs remains largely unknown.

The importance of studying PNSs stems from the fact that they originate at the fulcrum between the patient’s immune system and the tumor, thus providing an exceptional model to decipher tumor immune surveillance and action of cancer immunotherapy, but also mechanisms underlying the attack of neurons in Ab-mediated neurological disorders, with potentially relevant therapeutic implications.

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