Anti-CASPR2 clinical phenotypes correlate...

Antibodies against contactin-associated protein-like 2 (CASPR2-Abs) are found in patients with acquired neuromyotonia (NMT), limbic encephalitis (LE) and Morvan syndrome (MoS). Initial descriptions of MoS included both peripheral nerve hyperexcitability (PNH) and central nervous system (CNS) features, but the co-occurrence of LE and NMT in some patients has raised doubts about whether these cases should be labelled as MoS, blurring the lines between these three different clinical presentations.

They performed a cluster analysis, which is a statistical tool that allows classifying subjects of similar types into respective categories, to explore the distribution of symptoms in a cohort of CASPR2-Abs patients. 

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