Fundamental mechanistic insights from rare....

In this Review, Wiendl and al. summarize the key mechanistic insights that have been gained in these three rare neuroimmunological diseases and discuss the wider implications of these findings for the field of neuroimmunology. They highlight how a combination of findings in humans with these paradigmatic rare diseases and animal models for the in vivo validation of pathogenic pathways and the identification of new mechanisms enables triangulation of evidence.

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