Compartmentalized cytotoxic CD4+ T cell responses...
We performed single-cell RNA sequencing with paired T-cell receptor sequencing on immune cells isolated from blood and cerebrospinal fluid from six patients with Yo-PCD. Samples from individuals with multiple sclerosis, idiopathic intracranial hypertension and patients with ovarian cancer without neurological disease served as additional controls. Immune cell states, clonal expansion, and compartment-specific transcriptional programs were analyzed.
