Psychiatric symptoms in anti glutamic...

Limbic Encephalitis (LE) is a form of encephalitis involving the median temporal lobes, the amygdala and, less frequently, the fronto-basal and insular lobes, which may result from a viral infection (e.g., herpes simplex encephalitis) or from an autoimmune condition.

Several autoantibodies with a specific tropism towards the limbic structures have been identified and represent helpful markers for the diagnosis of LE.

Limbic Encephalitis associated with Glutamic Acid Decarboxylase (GAD) antibodies is difficult to diagnose due to its possible atypical presentation with neuropsychiatric and behavioral features. In this article, A. Vrillon and al. performed a systematic review of literature and retrieved 21 cases of anti GAD-associated LE with neuropsychiatric signs.

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